Wire Hair in Dog – Wh Locus Wh Locus

Genetics and characteristics Wire hair describes the coarse, bristly coat especially common in terrier breeds. It is also associated with a pattern of increased hair length around the chin, muzzle, and above the eyes (referred to as facial furnishings).

Gene RSPO2
Mutation 167bp insertion
Inheritance Autosomal dominant
Sample CHS (Cheek Swab), WBE (Whole Blood EDTA)
Method End-point PCR with agarose gel electrophoresis

Genetics and characteristics

Wire hair describes the coarse, bristly coat especially common in terrier breeds. It is also associated with a pattern of increased hair length around the chin, muzzle, and above the eyes (referred to as facial furnishings). A 167 bp insertion in R-spondin 2 gene (RSPO2) was associated with wire hair and furnishings. RSPO2 is a secreted activator of a signaling pathway implicated in several aspects of hair follicle biology. The trait is dominant to smooth coat.

 


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References:

Cadieu, E., Neff, M.W., Quignon, P., Walsh, K., Chase, K., Parker, H.G., Vonholdt, B.M., Rhue, A., Boyko, A., Byers, A., et al. (2009). Coat variation in the domestic dog is governed by variants in three genes. Science 326, 150–153.