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Selkirk Rex Curly Coat
| Acronym: | SRCC |
| Gene: | KRT71 |
| Mutation: | c.445-1G > C |
| Inheritance: | Autosomal dominant with incomplete penetrance |
| Sample type: | CHS (Cheek Swab), WBE (Whole Blood EDTA) |
Genetics and characteristics
Curly coat in cats is rare and it is associated with only a few cat breeds, but it is an important characteristic along with coat color, hair length, and growth pattern. Several rexoid or woolly hair conditions have been described in breeds such as LaPerm, Devon Rex, and Selkirk Rex cats. Most of those cats share a common mutation within the KRT71 gene that is also known as Cu (Curly) Locus. KRT71 encodes keratin 71, a major structural component of hair and its variants are resulting in a dysfunctional protein that prevents keratin from binding together in a regular pattern The cause of curly coat in Selkirk Rex cats is a single base pair change that alters the structure of keratin and consequently the hair and results in a curly phenotype.
Rexoid curl coat pattern shows an autosomal incomplete dominant mode of inheritance. That means Selkirk cats that carry one or both mutated KRT71 genes will develop a curvy coat, but there may be some differences in the curl style. A single copy of the variant produces wavy hair, and two copies produce a tighter curl as well as a slender body type with long ears. Early genetic testing can identify carriers of this salient feature and help breeders in future mating pairs selection.
Results Reported As
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References:
Gandolfi, B., Alhaddad, H., Joslin, S. E., Khan, R., Filler, S., Brem, G., Lyons, L. A. (2013). A splice variant in KRT71 is associated with curly coat phenotype of Selkirk Rex cats. Scientific reports, 3, 2000. https://doi.org/10.1038/srep02000
Filler, S., Alhaddad, H., Gandolfi, B., Kurushima, J. D., Cortes, A., Veit, C., Lyons, L. A., Brem, G. (2012). Selkirk Rex: morphological and genetic characterization of a new cat breed. The Journal of heredity, 103(5), 727–733. https://doi.org/10.1093/jhered/ess039