Curly Coat in Dogs – Cu Locus

Acronym:	Cu Locus
Gene:	KRT71
Mutation:	c.451C>T
Inheritance:	Autosomal incomplete dominant
Sample type:	CHS (Cheek Swab), WBE (Whole Blood EDTA)

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Genetics and characteristics

Hair shape, or curl, in dogs, is a complex trait that is difficult to classify, especially when comparing phenotypes across breeds. Extreme differences in phenotype are exemplified by the long, relatively straight hair of the Afghan Hound and the long, tightly curled hair of the Poodle. This locus is called Cu, and the two alleles CAC and Cu+, for straight and curly coats, respectively. Curly hair is known to be recessive. Intermediate phenotypes between these two extremes, such as the loose, spiral-shaped hair characteristic of Irish Water Spaniels, are described as kinky or wavy.

Genome-wide mapping identified an association between KRT71 coding alteration and curly coat. Analysis across breeds indicates that the variant allele, KRT71151W, is uncommon in straight coated breeds, but fixed in several curly- and wavy coated breeds. Inheritance of curly coat is non-Mendelian, and the KRT71151W allele is not found in some curly-coated breeds, such as the Curly Coated Retrievers. Some popular breeds of curly-coated dogs are the Irish Water Spaniel, the Curly-Coated Retriever, the Airedale Terrier, the Kerry Blue Terrier, etc.

 

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Results Reported As

 

 

 

 

 

 

 

 

 

 

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Reference:

Cadieu, E., Neff, M.W., Quignon, P., Walsh, K., Chase, K., Parker, H.G., Vonholdt, B.M., Rhue, A., Boyko, A., Byers, A., et al. (2009). Coat variation in the domestic dog is governed by variants in three genes. Science 326, 150–153.