Wire Hair in Dog – Wh Locus
Acronym: | Wh Locus |
Gene: | RSPO2 |
Mutation: | 167bp insertion |
Inheritance: | Autosomal dominant |
Sample type: | CHS (Cheek Swab), WBE (Whole Blood EDTA) |
Genetics and characteristics
Wire hair describes the coarse, bristly coat especially common in terrier breeds. It is also associated with a pattern of increased hair length around the chin, muzzle, and above the eyes (referred to as facial furnishings). A 167 bp insertion in R-spondin 2 gene (RSPO2) was associated with wire hair and furnishings. RSPO2 is a secreted activator of a signaling pathway implicated in several aspects of hair follicle biology. The trait is dominant to smooth coat.
Results Reported As
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References:
Cadieu, E., Neff, M.W., Quignon, P., Walsh, K., Chase, K., Parker, H.G., Vonholdt, B.M., Rhue, A., Boyko, A., Byers, A., et al. (2009). Coat variation in the domestic dog is governed by variants in three genes. Science 326, 150–153.