Wire Hair in Dog – Wh Locus

Acronym: Wh Locus
Gene: RSPO2
Mutation: 167bp insertion
Inheritance: Autosomal dominant
Sample type: CHS (Cheek Swab), WBE (Whole Blood EDTA)


Genetics and characteristics

Wire hair describes the coarse, bristly coat especially common in terrier breeds. It is also associated with a pattern of increased hair length around the chin, muzzle, and above the eyes (referred to as facial furnishings). A 167 bp insertion in R-spondin 2 gene (RSPO2) was associated with wire hair and furnishings. RSPO2 is a secreted activator of a signaling pathway implicated in several aspects of hair follicle biology. The trait is dominant to smooth coat.

 


Results Reported As

 
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References:

Cadieu, E., Neff, M.W., Quignon, P., Walsh, K., Chase, K., Parker, H.G., Vonholdt, B.M., Rhue, A., Boyko, A., Byers, A., et al. (2009). Coat variation in the domestic dog is governed by variants in three genes. Science 326, 150–153.

 


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Suitable for breeds

AFFENPINSCHER AFGHAN HOUND AIREDALE TERRIER AKITA ALANO ESPAÑOL (SPANISH BULLDOG) ALASKAN HUSKY ALASKAN KLEE KAI ALASKAN MALAMUTE ALASKAN SLED DOG ALPINE DACHSBRACKE AMERICAN AKITA AMERICAN BULLDOG AMERICAN BULLY AMERICAN COCKER SPANIEL AMERICAN ENGLISH COONHOUND AMERICAN ESKIMO DOG AMERICAN FOXHOUND AMERICAN HAIRLESS TERRIER AMERICAN LEOPARD HOUND AMERICAN MINI-PEI AMERICAN PITBULL TERRIER AMERICAN STAFFORDSHIRE TERRIER AMERICAN TOY FOX TERRIER AMERICAN WATER SPANIEL ANATOLIAN SHEPHERD DOG ANGLO-FRANÇAIS DE PETITE VÈNERIE APPENZELL CATTLE DOG ARIEGE POINTING DOG ARIEGEOIS ARTOIS HOUND
And for more 405 breeds