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Exercise-Induced Collapse (EIC)
| Acronym: | EIC |
| Gene: | DNM1 |
| Mutation: | c.767 G>T |
| Inheritance: | Autosomal recessive |
| Sample type: | CHS (Cheek Swab), WBE (Whole Blood EDTA) |
Genetics and characteristics
Exercise-induced collapse (EIC) is an autosomal recessive disorder and is characterized by episodic limb weakness, ataxia, and collapse induced by intense exercise and excitement in young adult, athletic dogs. Five to fifteen minutes of strenuous exercise causes dogs suffering from this condition to develop a ‘wobbly’ gait, which soon progresses to nonpainful, flaccid paraparesis and a loss of control of the rear limbs. The episode may progress to all four limbs. Collapse episodes usually last for 5–10 min, recovery is typically rapid, and after 30 min there is often complete recovery, but severe episodes are occasionally fatal.
It is most common among Labrador Retrievers and Current data shows that 30% to 40% of Labradors are carriers (with one copy of the mutation) and 3% to 13% of dogs are affected (with 2 copies) and susceptible to collapse. Since there are no detectable serum biochemical markers in collapsed dogs, diagnosis of EIC by laboratory examination is difficult. Identification of dogs prone to EIC is important so that activities that induce collapse can be avoided.
Results Reported As
Test Result |
Interpretation of test result |
CLEAR |
Tested mutation was not detected in animal with „clear“ result. Animal tested as clear has wild-type allele in homozygous state (i.e. two pairs of healthy alleles). It will not develop disease caused by tested mutation.* It will pass only wild-type allele to its offspring. |
CARRIER |
Tested mutation was detected in animal with „carrier“ result. Animal tested as carrier has one wild-type and one mutation allele, it is in heterozygous state. It will not develop disease caused by tested mutation.* It can pass wild-type or mutation allele to its offspring. |
AFFECTED |
Tested mutation was detected in animal with „affected“ result. Animal tested as affected has two copies of mutation alleles affecting the gene. It is likely the animal will experience a genetic disorder due to this mutation.** It will pass only mutation allele to its offspring. |
*Test excludes only tested mutation but not possible unknown mutations or factors that can lead to similar condition/symptoms.
** Potential unknown mutations or multiple other factors can possibly affect the likelihood of experiencing a genetic disorder.
References:
Furrow, E., Minor, K.M., Taylor, S.M., Mickelson, J.R., and Patterson, E.E. (2013). Relationship between dynamin 1 mutation status and characteristics of recurrent episodes of exercise-induced collapse in Labrador Retrievers. Journal of the American Veterinary Medical Association 242, 786–791.
Patterson, E.E., Minor, K.M., Tchernatynskaia, A.V., Taylor, S.M., Shelton, G.D., Ekenstedt, K.J., and Mickelson, J.R. (2008). A canine DNM1 mutation is highly associated with the syndrome of exercise-induced collapse. Nature Genetics 40, 1235–1239.
Taylor, S.M., Shmon, C.L., Adams, V.J., Mickelson, J.R., Patterson, E.N.E., and Shelton, G.D. (2009). Evaluations of labrador retrievers with exercise-induced collapse, including response to a standardized strenuous exercise protocol. J Am Anim Hosp Assoc 45, 3–13.