Dog Coat Color – B Locus (Brown)

Acronym: B Locus
Gene: TYRP1
Mutation: c.121T>A, c.991C>T, c.1033_1035del
Inheritance: Autosomal Recessive
Sample type: CHS (Cheek Swab), WBE (Whole Blood EDTA)


Genetics and characteristics

Brown locus, also known as the B locus, generates a brown dog coat color. Tyrosinase-related protein 1 (TYRP1) is a protein within the melanocyte that alters the color of the skin and hair of animals. This gene is refered to as the B locus and is responsible for brown versus black coat color with brown coat color inherited recessive to black. The three alleles of the Brown (B) locus are designated bs, bd and bc, a combination of any two of which will cause brown coat colour. In some breeds, such as Doberman Pinschers and Australian Shepherds, brown dogs are referred to as red. MC1R and TYRP1 comprise an example of interactive effects between loci on a single phenotypic trait: back coat color. A dog is not black unless it has a dominant allele at both MC1R and TYRP1.

 


Results Reported As

 
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References:

Schmutz, S.M., Berryere, T.G., and Goldfinch, A.D. (2002). TYRP1 and MC1R genotypes and their effects on coat color in dogs. Mamm. Genome 13, 380–387.

 


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Suitable for breeds

AFFENPINSCHER AFGHAN HOUND AIREDALE TERRIER AKITA ALANO ESPAÑOL (SPANISH BULLDOG) ALASKAN HUSKY ALASKAN KLEE KAI ALASKAN MALAMUTE ALASKAN SLED DOG ALPINE DACHSBRACKE AMERICAN AKITA AMERICAN BULLDOG AMERICAN BULLY AMERICAN COCKER SPANIEL AMERICAN ENGLISH COONHOUND AMERICAN ESKIMO DOG AMERICAN FOXHOUND AMERICAN HAIRLESS TERRIER AMERICAN LEOPARD HOUND AMERICAN MINI-PEI AMERICAN PITBULL TERRIER AMERICAN STAFFORDSHIRE TERRIER AMERICAN TOY FOX TERRIER AMERICAN WATER SPANIEL ANATOLIAN SHEPHERD DOG ANGLO-FRANÇAIS DE PETITE VÈNERIE APPENZELL CATTLE DOG ARIEGE POINTING DOG ARIEGEOIS ARTOIS HOUND
And for more 405 breeds