Nemaline Myopathy American Bulldog Type (NM)

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Acronyms: NM
Gene: NEB
Mutation: Point mutation
Mode of inheritance: Autosomal recessive
Breeds: American bulldog

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Product Description

Nemaline myopathy American Bulldog Type (NM)

Nemaline myopathy  (NM) is an inherited muscle disorder characterized by the presence of rod bodies in the skeletal muscle fibers. Canine form of nemaline myopathy has been diagnosed in the American Bulldog, Border Collie and Schipperke, but the causative mutation has been identified only in the American Bulldog dog. Except in dogs, the disorder has been recognized also in cats and humans, while in humans it makes the most common human congenital myopathy, accounting 17% of cases. An adult form of NM has been diagnosed in several mix-breed dogs, but as in humans, adult occurring forms of NM are not caused by the genetic heritage. To exclude other possible diseases with similar symptoms, when diagnosing NME differential diagnosis for polymyositis, Duchenne muscular dystrophy and muscle parasites are included.

Characteristics and Symptoms

Clinical symptoms in the affected dog include generalized muscle weakness, exercise intolerance, and tremors which usually start around 2 months of age. The owners often report that their dog since an early age is constantly shaking and is reluctant to exercise. The affected dog has a generalized atrophy, and the myopathy is relatively non-progressive. Muscle examination reveals an atrophy of the cervical and dorsal thoracic limb muscles as well as hypertrophy of the triceps muscles. Serum creatine kinase activities were mildly elevated. Compared to the healthy muscle, affected Americal Bulldogs showed a marked variability in myofiber size and present generalized atrophy. In most of muscles a rod-like inclusion bodies could be found, which are not present in a healthy muscle.

Genetics

Nemaline myopathy in American Bulldogs (NM) is caused by a nonsense mutation in NEB gene. NEB gene codes for nebulin protein (NEB) whose role is to stabilize the actin thin filament of skeletal muscle sarcomeres and is crucial for a proper muscle contraction. This specific mutation is directly connected to canine NM disorder, but a different mutation in the same gene has been also connected with the primary angle-closure glaucoma in Basset hounds.

Nemaline myopathy in American Bulldogs (NM) is inherited in an autosomal recessive pattern. Healthy parents of affected puppy are obligate heterozygotes and therefore carry one mutant allele. Heterozygotes have no symptoms. Dogs homozygous for the mutation will display the symptoms of the NM. At conception, when mating two carrier dogs, each cub has a 25% chance of being affected, a 50% chance of being an asymptomatic carrier, and a 25% chance of being unaffected and not a carrier.

References:

Evans, J. M. et al (2016) Exome sequencing reveals a nebulin nonsense mutation in a dog model of nemaline myopathy. Mamm Genome. 27(9-10):495-502. doi: 10.1007/s00335-016-9644-9.

Delauche AJ et al (1998) Nemaline rods in canine myopathies: 4 case reports and literature review. J Vet Intern Med 12(6):424-430

Nakamura RK et al (2012) Adult-onset nemaline myopathy in a dog presenting with persistent atrial standstill and primary hypothyroidism. J Small Anim Pract 53(6):357-360