Dog Coagulation Factor VII Deficiency (CFVIID)

40.90 € inc. Vat

Acronyms: CFVIID
Mutation: Point mutation
Mode of inheritance: Autosmal recessive
Breeds: Airedale Terrier, Beagle, Deerhound, Giant Schnauzer, Finnish Hound, Welsh Springer Spaniel

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Product Description

Dog Coagulation Factor VII Deficiency

Dog coagulation factor VII deficiency (cFVII), the most common autosomal recessive inherited factor deficiency associated with a mild to moderate bleeding tendency. Following vascular injury, canine coagulation factor VII deficiency, in combination with some other factors leads to the generation of thrombin, crucial in formation of blood cloth that stops bleeding. Although largely an asymptomatic defect, this autosomal recessive hemostatic disorder, can lead to excessive bleeding after surgery or trauma, hematoma formation, body cavity bleeding, and persistent uterine and vaginal hemorrhage. Clinical symptoms in canines can be reduced by transfusions with fresh plasma or blood, or administration of recombinant activated human FVII. However, treatments are only a temporary solution, because the half-life of FVII protein is only 3 to 4 h and, in canines, treatment with human proteins raises concern about antibody responses to those proteins, thus potentially limiting further therapy.


Callan, M.B., Aljamali, M.N., Margaritis, P., Griot-Wenk, M.E., Pollak, E.S., Werner, P., Giger, U., and High, K.A. (2006). A novel missense mutation responsible for factor VII deficiency in research Beagle colonies. J. Thromb. Haemost. 4, 2616–2622.

Carlstrom, L.P., Jens, J.K., Dobyns, M.E., Passage, M., Dickson, P.I., and Ellinwood, N.M. (2009). Inadvertent Propagation of Factor VII Deficiency in a Canine Mucopolysaccharidosis Type I Research Breeding Colony. Comp Med 59, 378–382.