Dog Coagulation Factor VII Deficiency
Dog coagulation factor VII deficiency (cFVII), the most common autosomal recessive inherited factor deficiency associated with a mild to moderate bleeding tendency. Following vascular injury, canine coagulation factor VII deficiency, in combination with some other factors leads to the generation of thrombin, crucial in formation of blood cloth that stops bleeding. Although largely an asymptomatic defect, this autosomal recessive hemostatic disorder, can lead to excessive bleeding after surgery or trauma, hematoma formation, body cavity bleeding, and persistent uterine and vaginal hemorrhage. Clinical symptoms in canines can be reduced by transfusions with fresh plasma or blood, or administration of recombinant activated human FVII. However, treatments are only a temporary solution, because the half-life of FVII protein is only 3 to 4 h and, in canines, treatment with human proteins raises concern about antibody responses to those proteins, thus potentially limiting further therapy.
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