Maligne Hyperthermie beim Hund (MH)

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Maligne Hyperthermie beim Hund (MH)

Maligne Hyperthermie beim Hund (MH)

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Abkürzungen:	CMH, MH
Gen:	RYR1
Mutation:	Punktmutation
Erbgang:	Autosomal-dominant
Rassen:	Alle Rassen

Art.-Nr.: CD033 Kategorien: Erbkrankheiten Hunde, Hunde Schlüsselworte: AFFENPINSCHER, AFGHAN HOUND, AIREDALE TERRIER, AKITA, ALASKAN MALAMUTE, ALPINE DACHSBRACKE, AMERICAN AKITA, AMERICAN COCKER SPANIEL, AMERICAN FOXHOUND, AMERICAN STAFFORDSHIRE TERRIER, AMERICAN WATER SPANIEL, ANATOLIAN SHEPHERD DOG, APPENZELL CATTLE DOG, ARIEGE POINTING DOG, ARIEGEOIS, ARTOIS HOUND, ATLAS MOUNTAIN DOG (AIDI), AUSTRALIAN CATTLE DOG, AUSTRALIAN KELPIE, AUSTRALIAN SHEPHERD, AUSTRALIAN SILKY TERRIER, AUSTRALIAN STUMPY TAIL CATTLE DOG, AUSTRALIAN TERRIER, AUSTRIAN BLACK AND TAN HOUND, AUSTRIAN PINSCHER, AUVERGNE POINTER, AZAWAKH, BASENJI, BASSET FAUVE DE BRETAGNE, BASSET HOUND, BAVARIAN MOUNTAIN SCENT HOUND, BEAGLE, BEAGLE HARRIER, BEARDED COLLIE, BEDLINGTON TERRIER, BELGIAN SHEPHERD DOG, BERGAMASCO SHEPHERD, BERGER DE BEAUCE, BERNESE MOUNTAIN DOG, BICHON FRISE, BILLY, BLACK AND TAN COONHOUND, BLOODHOUND, BLUE GASCONY BASSET, BLUE GASCONY GRIFFON, BLUE PICARDY SPANIEL, BOBTAIL, BOHEMIAN WIRE-HAIRED POINTING GRIFFON, BOLOGNESE, BORDER COLLIE, BORDER TERRIER, BORZOI - RUSSIAN HUNTING SIGHTHOUND, BOSNIAN AND HERZEGOVINIAN - CROATIAN SHEPHERD DOG, BOSNIAN BROKEN-HAIRED HOUND - CALLED BARAK, BOSTON TERRIER, BOURBONNAIS POINTING DOG, BOUVIER DES ARDENNES, BOUVIER DES FLANDRES, BOXER, BRAZILIAN TERRIER, BRIARD, BRIQUET GRIFFON VENDEEN, BRITTANY SPANIEL, BROHOLMER, BULL TERRIER, BULLDOG, BULLMASTIFF, BURGOS POINTING DOG, CAIRN TERRIER, CANAAN DOG, CANARIAN WARREN HOUND, CASTRO LABOREIRO DOG, CATALAN SHEEPDOG, CAUCASIAN SHEPHERD DOG, CAVALIER KING CHARLES SPANIEL, CENTRAL ASIA SHEPHERD DOG, CESKY TERRIER, CHESAPEAKE BAY RETRIEVER, CHIHUAHUA, CHINESE CRESTED DOG, CHOW CHOW, CIRNECO DELL'ETNA, CLUMBER SPANIEL, COARSE-HAIRED STYRIAN HOUND, COLLIE ROUGH, COLLIE SMOOTH, CONTINENTAL TOY SPANIEL, COTON DE TULEAR, CROATIAN SHEPHERD DOG, CURLY COATED RETRIEVER, CZECHOSLOVAKIAN WOLFDOG, DACHSHUND, DALMATIAN, DANDIE DINMONT TERRIER, DANISH-SWEDISH FARMDOG, DEERHOUND, DEUTSCH STICHELHAAR, DOBERMANN, DOGO ARGENTINO, DOGO CANARIO, DOGUE DE BORDEAUX, DRENTSCHE PARTRIDGE DOG, DREVER, DUTCH SCHAPENDOES, DUTCH SHEPHERD DOG, DUTCH SMOUSHOND, EAST SIBERIAN LAIKA, ENGLISH COCKER SPANIEL, ENGLISH FOXHOUND, ENGLISH POINTER, ENGLISH SETTER, ENGLISH SPRINGER SPANIEL, ENGLISH TOY TERRIER (BLACK &TAN), ENTLEBUCH CATTLE DOG, ESTRELA MOUNTAIN DOG, EURASIAN, FAWN BRITTANY GRIFFON, FIELD SPANIEL, FILA BRASILEIRO, FINNISH HOUND, FINNISH LAPPHUND, FINNISH SPITZ, FLAT COATED RETRIEVER, FOX TERRIER (SMOOTH), FOX TERRIER (WIRE), FRENCH BULLDOG, FRENCH POINTING DOG - GASCOGNE TYPE, FRENCH POINTING DOG - PYRENEAN TYPE, FRENCH SPANIEL, FRENCH TRICOLOUR HOUND, FRENCH WATER DOG, FRENCH WHITE & BLACK HOUND, FRENCH WHITE AND ORANGE HOUND, FRISIAN POINTING DOG, FRISIAN WATER DOG, GASCON SAINTONGEOIS, GERMAN HOUND, GERMAN HUNTING TERRIER, GERMAN LONG-HAIRED POINTING DOG, GERMAN PINSCHER, GERMAN SHEPHERD DOG, GERMAN SHORT- HAIRED POINTING DOG, GERMAN SPANIEL, GERMAN SPITZ, GERMAN WIRE- HAIRED POINTING DOG, GIANT SCHNAUZER, GOLDEN RETRIEVER, GORDON SETTER, GRAND BASSET GRIFFON VENDEEN, GRAND GRIFFON VENDEEN, GREAT ANGLO-FRENCH TRICOLOUR HOUND, GREAT ANGLO-FRENCH WHITE & ORANGE HOUND, GREAT ANGLO-FRENCH WHITE AND BLACK HOUND, GREAT DANE, GREAT GASCONY BLUE, GREAT SWISS MOUNTAIN DOG, GREENLAND DOG, GREYHOUND, GRIFFON BELGE, GRIFFON BRUXELLOIS, GRIFFON NIVERNAIS, HALDEN HOUND, HAMILTONSTÖVARE, HANOVERIAN SCENTHOUND, HARRIER, HAVANESE, HELLENIC HOUND, HOKKAIDO, HOVAWART, HUNGARIAN GREYHOUND, HUNGARIAN HOUND - TRANSYLVANIAN SCENT HOUND, HUNGARIAN SHORT-HAIRED POINTER (VIZSLA), HUNGARIAN WIRE-HAIRED POINTER, HYGEN HOUND, IBIZAN PODENCO, ICELANDIC SHEEPDOG, IRISCHER ROT-WEISSER SETTER, IRISCHER ROTER SETTER, IRISH GLEN OF IMAAL TERRIER, IRISH SOFT COATED WHEATEN TERRIER, IRISH TERRIER, IRISH WATER SPANIEL, IRISH WOLFHOUND, ISTRIAN SHORT-HAIRED SCENT HOUND, ISTRIAN WIRED-HAIRED SCENT HOUND, ITALIAN CORSO DOG, ITALIAN GREYHOUND, ITALIAN POINTING DOG, ITALIAN ROUGH-HAIRED SEGUGIO, ITALIAN SHORT-HAIRED HOUND, ITALIAN VOLPINO, JACK RUSSELL TERRIER, JÄMTHUND, JAPANESE CHIN, JAPANESE SPITZ, JAPANESE TERRIER, KAI, KARELIAN BEAR DOG, KARST SHEPHERD DOG, KERRY BLUE TERRIER, KING CHARLES SPANIEL, KISHU, KLEINER MÜNSTERLÄNDER, KOMONDOR, KOREA JINDO DOG, KROMFOHRLÄNDER, KUVASZ, LABRADOR RETRIEVER, LAKELAND TERRIER, LANDSEER (EUROPEAN CONTINENTAL TYPE), LAPPONIAN HERDER, LARGE MUNSTERLANDER, LEONBERGER, LHASA APSO, LITTLE LION DOG, LONG-HAIRED PYRENEAN SHEEPDOG, MAJORCA MASTIFF, MAJORCA SHEPHERD DOG, MALTESE, MANCHESTER TERRIER, MAREMMA AND THE ABRUZZES SHEEPDOG, MASTIFF, MEDIUM-SIZED ANGLO-FRENCH HOUND, MINIATURE BULL TERRIER, MINIATURE PINSCHER, MINIATURE SCHNAUZER, MONTENEGRIN MOUNTAIN HOUND, MUDI, NEAPOLITAN MASTIFF, NEDERLANDSE KOOIKERHONDJE, NEWFOUNDLAND, NORFOLK TERRIER, NORMAN ARTESIEN BASSET, NORRBOTTENSPITZ, NORWEGIAN BUHUND, NORWEGIAN ELKHOUND BLACK, NORWEGIAN ELKHOUND GREY, NORWEGIAN HOUND, NORWEGIAN LUNDEHUND, NORWICH TERRIER, NOVA SCOTIA DUCK TOLLING RETRIEVER, OLD DANISH POINTING DOG, OTTERHOUND, PARSON RUSSELL TERRIER, PEKINGESE, PERUVIAN HAIRLESS DOG, PETIT BASSET GRIFFON VENDEEN, PETIT BRABANÇON, PHARAOH HOUND, PICARDY SHEEPDOG, PICARDY SPANIEL, POITEVIN, POLISH GREYHOUND, POLISH HOUND, POLISH HUNTING DOG, POLISH LOWLAND SHEEPDOG, PONT-AUDEMER SPANIEL, POODLE, PORCELAINE, PORTUGUESE POINTING DOG, PORTUGUESE SHEEPDOG, PORTUGUESE WARREN HOUND-PORTUGUESE PODENGO, PORTUGUESE WATER DOG, PUDELPOINTER, PUG, PULI, PUMI, PYRENEAN MASTIFF, PYRENEAN MOUNTAIN DOG, PYRENEAN SHEEPDOG - SMOOTH FACED, RAFEIRO OF ALENTEJO, RHODESIAN RIDGEBACK, ROMAGNA WATER DOG, ROMANIAN CARPATHIAN SHEPHERD DOG, ROMANIAN MIORITIC SHEPHERD DOG, ROTTWEILER, RUSSIAN BLACK TERRIER, RUSSIAN TOY, RUSSIAN-EUROPEAN LAIKA, SAARLOOS WOLFDOG, SAINT GERMAIN POINTER, SAINT MIGUEL CATTLE DOG, SALUKI, SAMOYED, SCENT HOUND FROM THE SAVE VALLEY, SCHILLERSTÖVARE, SCHIPPERKE, SCHNAUZER, SCOTTISH TERRIER, SEALYHAM TERRIER, SERBIAN HOUND, SERBIAN TRICOLOUR HOUND, SHAR PEI, SHETLAND SHEEPDOG, SHIBA, SHIH TZU, SHIKOKU, SIBERIAN HUSKY, SKYE TERRIER, SLOUGHI, SLOVAKIAN CHUVACH, SLOVAKIAN HOUND, SM?LANDSSTÖVARE, SMALL BLUE GASCONY BLUE, SMALL SWISS HOUND, SOUTH RUSSIAN SHEPHERD DOG, SOUTHEASTERN EUROPEAN SHEPHERD, SPANISH GREYHOUND, SPANISH HOUND, SPANISH MASTIFF, SPANISH WATER DOG, SPINONE, ST. BERNARD, STAFFORDSHIRE BULL TERRIER, SUSSEX SPANIEL, SWEDISH LAPPHUND, SWEDISH VALLHUND, SWISS HOUND, TAIWAN DOG, TATRA SHEPHERD DOG, THAI BANGKAEW DOG, THAI RIDGEBACK DOG, TIBETAN MASTIFF, TIBETAN SPANIEL, TIBETAN TERRIER, TOSA, TYROLEAN HOUND, URUGUAYAN CIMARRON, WEIMARANER, WELSH CORGI CARDIGAN, WELSH CORGI PEMBROKE, WELSH SPRINGER SPANIEL, WELSH TERRIER, WEST HIGHLAND WHITE TERRIER, WEST SIBERIAN LAIKA, WESTPHALIAN DACHSBRACKE, WHIPPET, WHITE SWISS SHEPHERD DOG, WIRE-HAIRED POINTING GRIFFON KORTHALS, WIREHAIRED SLOVAKIAN POINTER, XOLOITZCUINTLE, YORKSHIRE TERRIER, YUGOSLAVIAN SHEPHERD DOG - SHARPLANINA

Beschreibung

Die Gentestbeschreibung

Maligne Hyperthermie beim Hund (MH)

Die maligne Hyperthermie beim Hund (MH) ist eine autosomal-dominant vererbte Störung des Skelettmuskels, charakterisiert durch Hyperkarbie, Rhabdomyolyse, allgemeine Kontraktur des Skelettmuskels, Herzrhythmusstörungen und Nierenversagen, das sich bei der Aufnahme flüchtiger Anästhetika und depolarisierender Muskelrelaxantien entwickelt. Wenn diese Mittel verabreicht werden, zeigen für MH anfällige Hunde Herzrasen, Hyperthermie, erhöhte Dioxidproduktion und sterben, falls das Anästhetikum nicht abgesetzt wird.

Referenzen:

Roberts, M.C., Mickelson, J.R., Patterson, E.E., Nelson, T.E., Armstrong, P.J., Brunson, D.B., and Hogan, K. (2001). Autosomal Dominant Canine Malignant Hyperthermia Is Caused by a Mutation in the Gene Encoding the Skeletal Muscle Calcium Release Channel (RYR1 ). Anesthesiology 95, 716–725 – 716–725.