Wire Hair in Dog – Wh Locus
Wire hair describes the coarse, bristly coat especially common in terrier breeds. It is also associated with a pattern of increased hair length around the chin, muzzle and above the eyes (referred to as facial furnishings). A 167 bp insertion in R-spondin 2 gene (RSPO2) was associated with wire hair and furnishings. RSPO2 is a secreted activator of a signalling pathway implicated in several aspects of hair follicle biology. The trait is dominant to smooth coat.
Cadieu, E., Neff, M.W., Quignon, P., Walsh, K., Chase, K., Parker, H.G., Vonholdt, B.M., Rhue, A., Boyko, A., Byers, A., et al. (2009). Coat variation in the domestic dog is governed by variants in three genes. Science 326, 150–153.