Severe combined immunodeficiency disease (SCID) represents a heterogeneous group of disorders that are characterized by a failure in humoral and cell-mediated immunity. The inheritance of SCID can be either autosomal or X-linked recessive. Clinically, XSCID is characterized by failure to thrive, increased susceptibility to bacterial and viral pathogens, and a lack of palpable peripheral lymph nodes. XSCID is invariably fatal in dogs by 4 months of age unless treated by bone marrow transplantation or provision of a germ-free environment.
Richard L. Somberg, R.P.P. (1995). A single nucleotide insertion in the canine interleukin-2 receptor gamma chain results in X-linked severe combined immunodeficiency disease. Veterinary Immunology and Immunopathology 203–213.