Severe Combined Immunodeficiency Disease, X-linked Basset Hound type (XSCID)

50.90 € inc. Vat

Acronyms: SCID, XSCID
Gene: IL2RG
Mutation: Deletion
Mode of inheritance: X-linked recessive
Breeds: Basset Hound

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SKU: CD052 Categories: , Tag:

Product Description

Severe combined immunodeficiency disease (SCID) represents a heterogeneous group of disorders that are characterized by a failure in humoral and cell-mediated immunity. The inheritance of SCID can be either autosomal or X-linked recessive. Clinically, XSCID is characterized by failure to thrive, increased susceptibility to bacterial and viral pathogens, and a lack of palpable peripheral lymph nodes. XSCID is invariably fatal in dogs by 4 months of age unless treated by bone marrow transplantation or provision of a germ-free environment.



Richard L. Somberg, R.P.P. (1995). A single nucleotide insertion in the canine interleukin-2 receptor gamma chain results in X-linked severe combined immunodeficiency disease. Veterinary Immunology and Immunopathology 203–213.