Musladin-Lueke syndrome (MLS)
Musladin-Lueke Syndrome (MLS) is a hereditary disorder affecting Beagle dogs that manifests with extensive fibrosis of the skin and joints. It is multi-systemic, with involvement of multiple organs, including bone, heart, skin, and muscle. Originally called ‘‘Chinese beagle syndrome’’, disease was subsequently renamed after two noted beagle breeders, Musladin and Lueke, and is characterized by short stature, thick, taut skin, and severely restricted joint mobility. Affected dogs also have broad skulls with wide-set slanted eyes, creased ears, a hopping, ‘‘tip-toe’’ gait, and pleasant temperaments.
Musladin-Lueke Syndrome is inherited as a recessive trait. That means that for a pup to be affected, they must have two copies of the defective gene. For this to happen, both the parents must be carriers. They each have one copy of the defective gene that they passed on to the unlucky pup. They do not show signs of the disease because they also have one copy of the normal gene which is enough for their brains to function normally.
Bader, H.L., Ruhe, A.L., Wang, L.W., Wong, A.K., Walsh, K.F., Packer, R.A., Mitelman, J., Robertson, K.R., O’Brien, D.P., Broman, K.W., et al. (2010). An ADAMTSL2 Founder Mutation Causes Musladin-Lueke Syndrome, a Heritable Disorder of Beagle Dogs, Featuring Stiff Skin and Joint Contractures. PLoS ONE 5, e12817.