Multidrug Resistance (MDR1)

49.90 € inc. Vat

Acronyms: MDR1
Gene: ABCB1
Mutation: Deletion
Mode of inheritance: Autosomal recessive
Breeds: Australian Shepherd, White Swiss Shepherd Dog, Border Collie, Collie Rough, Collie Smooth, German Shepherd Dog, Bobtail, Shetland Sheepdog, Whippet

Animal ID *

Name or unique identification of your animal microchip number, tattoo number, etc

SKU: CD034 Categories: , Tags: , , , , , , , , ,

Product Description

Multidrug resistance (MDR1)

Multidrug resistance is disease represented as hypersensitivity for the certain antiparasitic and several other drugs that predisposes animals to a potentially fatal neurotoxicosis. Disease is caused by degeneration of P-glycoprotein, a protein normally expressed on brain capillary endothelial cells that functions as part of the blood-brain barrier to pump drugs out of the CNS. That way the blood-brain barrier limits the passage of drugs into the NS. Dogs with the gene deletion have increased brain concentrations of drugs including ivermectin, moxidectin, loperamide, and corticosteroids.

Dogs homozygous for the mutation do not express a functional P-glycoprotein and show increased sensitivity to many drugs. Regarding some of these drugs, brain penetration is highly increased, and the dogs develop severe neurotoxicosis, even when the drugs are administered at a normal therapeutic dosage, as in the case of ivermectin and doramectin. Genetic testing allows us to detect the mutation, but it is suggested that demonstration of only one mutation in the canine MDR1 gene cannot completely ensure security from adverse effects of the substrate drugs of P- glycoprotein.

References

Dowling, P. (2007). Pharmacogenetics: it’s not just about ivermectin in collies. The Canadian Veterinary Journal. La Revue Vétérinaire Canadienne 47, 1165–1168.

Mizukami, K., Chang, H.-S., Yabuki, A., Kawamichi, T., Hossain, M.A., Rahman, M.M., Uddin, M.M., and Yamato, O. (2012). Rapid genotyping assays for the 4-base pair deletion of canine MDR1/ABCB1 gene and low frequency of the mutant allele in Border Collie dogs. Journal of Veterinary Diagnostic Investigation 24, 127–134.

Neff, M.W., Robertson, K.R., Wong, A.K., Safra, N., Broman, K.W., Slatkin, M., Mealey, K.L., and Pedersen, N.C. (2004). Breed distribution and history of canine mdr1-1Δ, a pharmacogenetic mutation that marks the emergence of breeds from the collie lineage. PNAS 101, 11725–11730.