Intestinal Cobalamin Malabsorption Beagle Type (IGS)

Acronym: IGS
Gene: CUBN
Mutation: c.786delC
Inheritance: Autosomal recessive
Sample type: CHS (Cheek Swab), WBE (Whole Blood EDTA)


Genetics and characteristics

Intestinal cobalamin malabsorption Beagle Type (IGS) is a hereditary disorder affecting Beagles. Cobalamin, known as vitamin B12, plays an important role in many metabolic and synthesis pathways. Animals, as well as other higher organisms, are unable to synthesize cobalamin and need to obtain it by dietary intake. The uptake of dietary cobalamin requires several endogenous proteins. In Beagles a mutation in a gene coding for cubilin occurs, a protein that together with amnionless protein constitutes a receptor for the cobalamin-GIF complex. The mutation leads to cobalamin malabsorption which results in low levels of serum cobalamin, hyperhomocysteinemia, and methylmalonic aciduria. Clinical signs include lethargy, inappetence, failure to gain weight and failure to grow, macrocytosis, and neutropenia. In cobalamin-deficient Beagles, a degenerative liver disease develops. Clinical recovery can be achieved with regular parenteral cobalamin supplementation. The carrier frequency is 9%.

 


Results Reported As

 
Test Result
Interpretation of test result
CLEAR
Tested mutation was not detected in animal with „clear“ result. Animal tested as clear has wild-type allele in homozygous state (i.e. two pairs of healthy alleles). It will not develop disease caused by tested mutation.* It will pass only wild-type allele to its offspring.
CARRIER
Tested mutation was detected in animal with „carrier“ result. Animal tested as carrier has one wild-type and one mutation allele, it is in heterozygous state. It will not develop disease caused by tested mutation.* It can pass wild-type or mutation allele to its offspring.
AFFECTED
Tested mutation was detected in animal with „affected“ result. Animal tested as affected has two copies of mutation alleles affecting the gene. It is likely the animal will experience a genetic disorder due to this mutation.** It will pass only mutation allele to its offspring.

 

 

 

 

 

 

 

 

 

 

*Test excludes only tested mutation but not possible unknown mutations or factors that can lead to similar condition/symptoms.

** Potential unknown mutations or multiple other factors can possibly affect the likelihood of experiencing a genetic disorder.

 


References:

Drögemüller, M., Jagannathan, V., Howard, J., Bruggmann, R., Drögemüller, C., Ruetten, M., Leeb, T., and Kook, P.H. (2014). A frameshift mutation in the cubilin gene (CUBN) in Beagles with Imerslund-Gräsbeck syndrome (selective cobalamin malabsorption). Anim. Genet. 45, 148–150.

Fyfe, J.C., Hemker, S.L., Venta, P.J., Fitzgerald, C.A., Outerbridge, C.A., Myers, S.L., and Giger, U. (2013). An exon 53 frameshift mutation in CUBN abrogates cubam function and causes Imerslund-Gräsbeck syndrome in dogs. Mol. Genet. Metab. 109, 390–396.

Owczarek-Lipska, M., Jagannathan, V., Drögemüller, C., Lutz, S., Glanemann, B., Leeb, T., and Kook, P.H. (2013). A frameshift mutation in the cubilin gene (CUBN) in Border Collies with Imerslund-Gräsbeck syndrome (selective cobalamin malabsorption). PLoS ONE 8, e61144.

 


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Suitable for breeds

BEAGLE