POAG Petit Basset Griffon Vendeen Type

54.90 € inc. Vat

Acronyms: POAG
Gene: ADAMTS17
Mutation: Inversion
Mode of inheritance: Autosomal recessive
Breeds: Petit Basset Griffon Vendeen

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Product Description

POAG Petit Basset Griffon Vendeen Type

POAG Petit Basset Griffon Vendeen Type is an inherited ocular neuropathy caused by a mutation in ADAMTS17 gene. POAG stands for ”primary open-angle glaucoma” a specific form of disorder which is part of a wide group of disorders generally known as glaucoma. Glaucoma can be divided in two different forms of the disorder, primary and secondary glaucoma. Primary glaucoma is characterized by its onset without any other ocular cause, while secondary glaucoma appears when another cause is present, which triggers glaucoma. Except in Petit Basser Griffon Vendeen breed, POAG has been identified also in other dog breeds: Shar Pei, Beagle, Norwegian Elkhound, Basset Hound and Basset Fauve de Bretagne.

Characteristics and Symptoms

The first case of POAG  Petit Basset Griffon Vendeen Type was recorded in the United Kingdom in 1996. First symptoms usually start to develop between 3 to4 years of age, equally in both sexes. The disorder is characterized by elevated intraocular pressure and lens subluxation. The pectinate ligament abnormality and the closure of iridocorneal angle do not appear until the late stages of the disease, followed by retinal degeneration and a cupping deformation of the optic papilla. The disorder is usually painless, which results in late diagnosing of the disorder, most commonly when the onset of vision loss occurs.

POAG Petit Basset Griffon Vendeen Type Genetics

POAG Petit Basset Griffon Vendeen Type is caused by inversion mutation within ADAMTS17 gene. The disorder is inherited as an autosomal recessive disorder. Healthy parents of an affected dog are obligate heterozygotes and therefore carry one mutant allele. Heterozygotes are carriers and show no symptoms. At conception, each cub has a 25% chance of being affected, a 50% chance of being an asymptomatic carrier, and a 25% chance of being unaffected and not a carrier.


Forman, O. P., Pettitt, L., Komaromy, A. M., Bedford, P., Mellersh, C. (2015) A Novel Genome-Wide Association Study Approach Using Genotyping by Exome Sequencing Leads to the Identification of a Primary Open Angle Glaucoma Associated Inversion Disrupting ADAMTS17. PloS ONE 10(12): e0143546. doi: 10.1371/journal.pone.0143546.