Hyperuricosuria, the excessive excretion of uric acid in the urine, is a condition that predisposes dogs to urate urolithiasis. Dogs, like other animals excrete waste products in their urine, only unlike other animals one of the differentiating waste products of dogs metabolism is uric acid. This leads to high levels of uric acid in the urine and blood. In dogs, high uric acid levels result in urate urolithiasis, bladder stones that often have to be removed surgically. Breed-specific prevalence of urate urolithiasis, when caused by the hyperuricosuria mutation, can be lowered over time by decreasing the frequency of the mutant allele in the breeding populations. A DNA-based test for hyperuricosuria is available to assist veterinarians in the diagnosis of the underlying cause of urate urolithiasis. This DNA test may also be used to genotype breeding dogs and aid breeders in reducing the incidence of hyperuricosuria and urate urolithiasis in susceptible breeds.
Karmi, N., Safra, N., Young, A., and Bannasch, D.L. (2010). Validation of a urine test and characterization of the putative genetic mutation for hyperuricosuria in Bulldogs and Black Russian Terriers. American Journal of Veterinary Research 71, 909–914.