Product Description

Golden retriever muscular dystrophy (GRMD)

Golden retriever muscular dystrophy (GRMD) is a progressive, fatal disease characterized by degeneration of skeletal and cardiac muscle, but some muscles paradoxically undergo hypertrophy. Signs of disease show soon after birth because affected pups are often ineffectual sucklers. Although all Golden retriever muscular dystrophy (GRMD) dogs feature a total absence of dystrophin, phenotypic variability is frequently observed. Some severely-affected pups survive only a few days, while other dogs that survive for years with mild clinical involvement have also been documented.

References:

Brinkmeyer-Langford, C., and Kornegay, J.N. (2013). Comparative Genomics of X-linked Muscular Dystrophies: The Golden Retriever Model. Curr Genomics 14, 330–342.

Kornegay, J.N., Bogan, J.R., Bogan, D.J., Childers, M.K., Li, J., Nghiem, P., Detwiler, D.A., Larsen, C.A., Grange, R.W., Bhavaraju-Sanka, R.K., et al. (2012). Canine models of Duchenne muscular dystrophy and their use in therapeutic strategies. Mammalian Genome 23, 85–108.