Product Description
Dog Ichthyosis / Epidermolytic hyperkeratosis
Dog ichthyosis a hereditary, monogenic, cornification disorder, appearing early and persisting for life. In veterinary medicine, ichthyosis is now commonly classified into either epidermolytic or non-epidermolytic subtypes. Most reported cases in dogs are non-epidermolytic with heterogeneous clinical, histopathological and ultrastructural profiles.
Epidermiolitic hyperkeratosis / Ichthiosys is skin disorder transmitted as a recessive trait through an extended pedigree of Norfolk terrier dogs caused by mutation in gene encoding keratin 10. Affected dogs display lesions from birth through adulthood with all of the hallmarks of a mild, superficial, nonpalmar /plantar epidermolytic ichthyosis while heterozygotes are clinically and histologically normal.
Reference
Guaguere, E., Bensignor, E., Küry, S., Degorce-Rubiales, F., Muller, A., Herbin, L., Fontaine, J., and André, C. (2009). Clinical, histopathological and genetic data of ichthyosis in the golden retriever: a prospective study. J Small Anim Pract 50, 227–235.
Gross, T.L., Ihrke, P.J., Walder, E.J. & Affolter, V.K. (2005): Chapter 8: Diseases with abnormal cornification. 2.nd edt. In: T.L. Gross (ed.): Skin Diseases of the Dog and Cat: Clinical and Histopathological Diagnosis. Blackwell Science Ltd, UK, pp. 161-198.