Dog Ichthyosis / Epidermolytic Hyperkeratosis

54.90 € inc. Vat

Acronyms:
Gene: KRT10
Mutation: Point mutation
Mode of inheritance: Autosomal recessive
Breeds: Norfolk Terrier

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Product Description

Dog Ichthyosis / Epidermolytic hyperkeratosis

Dog ichthyosis a hereditary, monogenic, cornification disorder, appearing early and persisting for life. In veterinary medicine, ichthyosis is now commonly classified into either epidermolytic or non-epidermolytic subtypes. Most reported cases in dogs are non-epidermolytic with heterogeneous clinical, histopathological and ultrastructural profiles.

Epidermiolitic hyperkeratosis / Ichthiosys is skin disorder transmitted as a recessive trait through an extended pedigree of Norfolk terrier dogs caused by mutation in gene encoding keratin 10. Affected dogs display lesions from birth through adulthood with all of the hallmarks of a mild, superficial, nonpalmar /plantar epidermolytic ichthyosis while heterozygotes are clinically and histologically normal.

Reference

Credille, K.M., Barnhart, K.F., Minor, J.S., and Dunstan, R.W. (2005). Mild recessive epidermolytic hyperkeratosis associated with a novel keratin 10 donor splice-site mutation in a family of Norfolk terrier dogs. Br. J. Dermatol. 153, 51–58.

Guaguere, E., Bensignor, E., Küry, S., Degorce-Rubiales, F., Muller, A., Herbin, L., Fontaine, J., and André, C. (2009). Clinical, histopathological and genetic data of ichthyosis in the golden retriever: a prospective study. J Small Anim Pract 50, 227–235.

Gross, T.L., Ihrke, P.J., Walder, E.J. & Affolter, V.K. (2005): Chapter 8: Diseases with abnormal cornification. 2.nd edt. In: T.L. Gross (ed.): Skin Diseases of the Dog and Cat: Clinical and Histopathological Diagnosis. Blackwell Science Ltd, UK, pp. 161-198.