Canine multifocal retinopathy 3 (CMR3)
Canine multifocal retinopathy 3 (CMR3) is a recessively inherited eye disease, which is afecting the retina of the dog. Canine multifocal retinopathy 3 belongs to a group of inherited retinal disorders primarily caused by mutations scattered throughout the entire BEST1, a gene necessary for retinal pigment epithelium (RPE) function. Salient fundus changes are usually present in animals affected with CMR before 4 months of age and are characterized by multifocal areas of retinal which in older dogs progress to multifocal areas of outer retinal atrophy. It seems to be selflimited in most cases, although vision loss has also been described. So far, a specific treatment is not known.
Guziewicz, K.E., Slavik, J., Lindauer, S.J.P., Aguirre, G.D., and Zangerl, B. (2011). Molecular Consequences of BEST1 Gene Mutations in Canine Multifocal Retinopathy Predict Functional Implications for Human Bestrophinopathies. Invest Ophthalmol Vis Sci 52, 4497–4505.
Zangerl, B., Wickström, K., Slavik, J., Lindauer, S.J., Ahonen, S., Schelling, C., Lohi, H., Guziewicz, K.E., and Aguirre, G.D. (2010). Assessment of canine BEST1 variations identifies new mutations and establishes an independent bestrophinopathy model (cmr3). Mol Vis 16, 2791–2804.