Product Description

Canine multifocal retinopathy 2

Canine multifocal retinopathy 2 is an inherited disease in dogs affecting the retina. The disease belongs to a group of inherited retinal disorders primarily caused by mutations scattered throughout the entire BEST1, a gene necessary for retinal pigment epithelium (RPE) function. Salient fundus changes are usually present in animals affected with CMR before 4 months of age and are characterized by multifocal areas of retinal which in older dogs progress to multifocal areas of outer retinal atrophy. These multifocal areas of retinal are typically found in both eyes and can appear gray, tan, orange or pink and vary in number, size and location. It seems to be selflimited in most cases, although vision loss has also been described. So far, a specific treatment is not known.

References:

Guziewicz, K.E., Slavik, J., Lindauer, S.J.P., Aguirre, G.D., and Zangerl, B. (2011). Molecular Consequences of BEST1 Gene Mutations in Canine Multifocal Retinopathy Predict Functional Implications for Human Bestrophinopathies. Invest Ophthalmol Vis Sci 52, 4497–4505.

Hoffmann, I., Guziewicz, K.E., Zangerl, B., Aguirre, G.D., and Mardin, C.Y. (2012). Canine multifocal retinopathy in the Australian Shepherd: a case report. Vet Ophthalmol 15 Suppl 2, 134–138.

Zangerl, B., Wickström, K., Slavik, J., Lindauer, S.J., Ahonen, S., Schelling, C., Lohi, H., Guziewicz, K.E., and Aguirre, G.D. (2010). Assessment of canine BEST1 variations identifies new mutations and establishes an independent bestrophinopathy model (cmr3). Mol Vis 16, 2791–2804.